International Society of Non-Antibiotics (ISN)
Så oprulles skrækscenariet igen også for Dansk Veterinærtidsskrifts læsere.
Progress in the Basic and Clinical Studies in the
Reversal of Drug Resistance.
Thursday 19 September 2013
A Symposium on the occasion of the
70th birthday of
Dr. Jette Elisabeth Kristiansen
35 years in Paul Ehrlich’s footsteps
”There is no doubt about it: We are really able to reverse resistance using modern methylene blue derivatives”
Reversering af resistens
(Reversal of Resistance)
Non-antibiotika i behandlingen af infektions-sygdomme forårsaget af følsomme og resistente mikro- organismer hos mennesker og dyr.
Herbicure Healthcare Bio-Herbal Research Foundation
Saral Dighi (E), Boral, Kolkata-700154
Ex- Professor Emeritus of Microbiology
Department of Pharmaceutical Technology
Jadavpur University, Kolkata- 700032
Adress: , Sundgade 54, 6320 Egernsund, Denmark
Tel: +45 74 632 888 - E-mail:firstname.lastname@example.org
Rua Junqueira 96 1349-008 Lisboa, Portugal.
E-mail: email@example.com. -
Website at University of Szeged:www.szote.u-szeged.hu/medmicro/mikro.html
Website at the Szeged Foundation for Cancer Reserach:www.szegedirakkutatasert.hu
Website at Johns Hopkins: www.hopkinsmedicine.org/dom/tb_lab/students_staff/noton.html
Publication Links: www.researchgate.net/profile/Noton_Dutta2/publications and
Articles on non-antibiotics:
Only 25% of bacterial membrane transporters have functional annotation owing to the difficulty of experimental study and of accurate prediction of their function. Here we report a sequence-independent method for high-throughput mining of novel transporters. The method is based on ligand-responsive biosensor systems that enable selective growth of cells only if they encode a ligand-specific importer. We developed such a synthetic selection system for thiamine pyrophosphate and mined soil and gut metagenomes for thiamine-uptake functions. We identified several members of a novel class of thiamine transporters, PnuT, which is widely distributed across multiple bacterial phyla. We demonstrate that with modular replacement of the biosensor, we could expand our method to xanthine and identify xanthine permeases from gut and soil metagenomes. Our results demonstrate how synthetic-biology approaches can effectively be deployed to functionally mine metagenomes and elucidate sequence–function relationships of small-molecule transport systems in bacteria.
on Sensitivity and Invasion of Gram-positive Bacteria PhD-Thesis by Oliver Hendrics, University of Southern
Modification and Reversal of Resistance in Micro-organisms with Selected Non-antibiotics and their Stereoisomeric Analogs: New Efflux Inhibitors?
Jette E. Kristiansen1, Oliver Hendricks1, Thomas Delvin2, Trine S. Butterworth1 & Jørn B. Christensen3.
Links to articles on non-antibiotics:
Society Board members and contacts:
MRSA – igen – igen !